A brief introduction to Sirius, our history and products
Sirius Analytical make instruments to measure physicochemical properties of drugs - specifically pKa, logP, logD, solubility and dissolution. Starting with our first instrument PCA101 in 1990, we brought order to this analytical topic.
Our GLpKa instrument is widely used across the industry for pKa and logP measurement. Our new SiriusT3 instrument is the latest addition to our range of titrators. Throughout Sirius' history, we have been innovators. We introduced the standard of reporting pKas in 0.15M KCl ionic strength, Yasuda-Shedlovsky plots to obtain aqueous pKa from values measured in cosolvents, the use of Target Factor Analysis to obtain pKa from UV spectroscopic data, pH-metric measurement of logP, and, solubility measurement by CheqSol.
With over 50 Sirius-authored papers and chapters, and hundreds of oral presentations and posters at scientific meetings, Sirius is truly a leader in this field.
Market research tells us the assays and improvements that customers want, and our chemists work side-by-side with software engineers to develop them. We responded to requests for faster assays with lower sample weights by introducing Fast D-PAS measurement of pKa.
Sirius RefinementPro brings all our assays together into a powerful program for controlling instruments, manipulating drug physchem data and calculating results. In parallel with our Pharma instruments we have applied our skills in analytical QC, creating GLpH and Vinotrate.
Sirius is a privately-owned company operating from a modern facility in England’s beautiful county of East Sussex. Our customers are in pharmaceutical research, as well as in QC labs and wineries. Customers in North America are supported from our Beverly, MA office. Distributors represent us in Japan, China, Korea, India, Malaysia and some European countries.
Latest Sirius Posters Available for download
01.08.09
Our latest posters, including Solubility & Dissolution measurements in excipients and FaSSIF/FeSSIF media and high throughput pKa measurements, are available for download.
New Scientific Paper Published
07.12.09
New paper from Sirius explains how our solubility measurements work, and introduces new methods for evaluating supersaturation.
PhysChem Forum 8
23.03.10
Sirius are sponsors and exhibitors at the next PhysChem Forum being held at Pfizer in Sandwich, UK.
ADMET Europe 2010
08.04.10
Sirius will be exhibiting and speaking at ADMET Europe 2010 in Munich. Visit us on booth #12.