A brief introduction to Sirius, our history and products

Sirius makes instruments to measure physicochemical properties of ionizable drugs. Starting with our first instrument PCA101 in 1990, we brought order to this analytical topic. Our GLpKa instrument is now widely used for pKa and logP measurement. Throughout Sirius' history, we have been innovators. We introduced the standard of reporting pKa in 0.15 M KCl ionic strength, Yasuda-Shedlovsky plots to obtain aqueous pKa from values measured in cosolvents, the use of Target Factor Analysis to obtain pKa from pH-UV data, pH-metric measurement of logP, and, solubility measurement by CheqSol. With some 50 Sirius-authored papers and chapters, and hundreds of oral presentations and posters at scientific meetings, Sirius is truly a leader in this field.

Market research tells us the assays and improvements that customers want, and our chemists work side-by-side with software engineers to develop them. We responded to requests for faster assays with lower sample weights by introducing Fast D-PAS measurement of pKa.

Sirius RefinementPro brings all our assays together into a powerful program for controlling instruments, manipulating drug physchem data and calculating results. In parallel with our Pharma instruments we have applied our skills in analytical QC, creating GLpH and Vinotrate.

Sirius is a privately-owned company operating from a modern facility in England’s beautiful county of East Sussex. Our customers are in pharmaceutical research, as well as in QC labs and wineries. Customers in the US are supported from our New Jersey office. Distributors represent us in Japan, Korea, India and several European countries.