Sirius News
New paper - Study of pH-dependent solubility of organic bases. Revisit of Henderson-Hasselbalch relationship.
This new paper looks in detail at the relationship between Henderson-Hasselbalch calculated pH-solubility profiles and measured pH-dependent solubility data. Henderson-Hasselbalch is shown to produce reliable predictions of the pH-dependent aqueous solubility and deviations in behaviour can be explained by consideration of different salt compositions.
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New paper - New Ideas about the Solubility of Drugs
This new paper describes in detail our methods for solubility and supersaturation measurement, including a new method for visualising the extent and duration of supersaturation - the Neutral Species Concentration Profile.
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Sirius Analytical launch new SiriusT3 instrument for fully automated ionisation, lipophilicity and solubility measurement
Sirius Analytical Ltd., (UK), a leading provider of instrumentation and analytical services to the pharmaceutical and biotech industry, have launched a new automated instrument for measurement of ionisation (pKa), lipophilicity (logP/D) and solubility (kinetic and intrinsic) using sub-milligram quantities of drug sample.
The SiriusT3 system is a new state of the art hardware platform designed by Sirius to bring a new level of automation and quality to these difficult measurements.
Comprised of three separate hardware modules (Dispenser, Titrator and Autoloader), the SiriusT3 offers unparalleled automation features including automatic precision dispensing of all assay reagents, automated movement of experiment probes through buffer calibration positions and cleaning stations, built in automatic turbidity sensing and a built in ultrasonic bath for handling even the most insoluble drug candidates.
The SiriusT3 can be obtained in a variety of different configurations, from low to high throughput, suiting the needs of both early discovery screening departments and late stage formulation groups. A clear and straightforward upgrade route allows throughput to be expanded as and when required.
The SiriusT3 Autoloader module supports 192 assay positions and in conjunction with Sirius' unique Fast UV pKa method, it can screen compounds for pKas in just 4 minutes per assay, allowing for hundreds of high quality measurements per day, with 40 to 50 datapoints measured directly by a pH electrode and multi-wavelength UV/Vis spectroscopy system.
SiriusT3 assay setup and data analysis software has been designed to offer maximum ease of use and features built-in optimized routines for handling even the most challenging of compounds.
Jon Mole, Sirius' Technical Sales Manager, said "The launch of the SiriusT3 represents the culmination of over six years of intensive product development and customer research to deliver the next generation system for pKa, logP/D and solubility by automated titration. With a new miniaturized platform we have delivered a system which can surpass the quality and automation of our industry renowned GLpKa system whilst reducing sample consumption by up 90%. Other commercial systems which rely on large sample quantities, manual movement of assay probes, or the use of multiple pH buffers for data collection cannot match the reliability and depth of information that the SiriusT3 can provide with ease."
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New paper - Fast Solubility measurements using the Delta-8
This new paper illustrates how the Delta-8 may be used to quickly profile the solubility of drugs in a 96 well plate format. A linear correlation against equilibrium solubility is demonstrated.
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New paper introduces LogP vs. LogS graph
We plotted logP vs. LogS for 84 drugs, and found that they cluster according to their melting points, H-bonding capacity and BCS Classification. Read this fascinating story in our latest publication.
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The challenge: can you predict drug solubility?
Solubility is a key physicochemical property of drug molecules, which greatly influences their bioavailability and pharmacokinetics. Unfortunately, because serious deficiencies exist in the consistency and reliability of solubility data in the literature, it has been difficult to develop reliable software for accurate prediction of solubility from structure; systematic errors and lack of metadata associated with measurements greatly reduce the confidence in current models. To address this, Bobby Glen and his team at the University of Cambridge have been accurately measuring intrinsic solubility values, and have reported results for a diverse set of 100 drug-like molecules at 25ş C and an ionic strength of 0.15 M using the CheqSol approach introduced in 2005 by Sirius Analytical Ltd. of Forest Row, UK. This is a highly reproducible potentiometric technique that ensures the thermodynamic equilibrium is reached rapidly. Results with a coefficient of variation higher than 4% were rejected. In addition, the Potentiometric Cycling for Polymorph Creation method, [PC]2 , was used to obtain multiple polymorph forms from aqueous solution. The Cambridge team now challenges researchers to predict the intrinsic solubility of 32 other drug-like molecules that have been measured but are yet to be published.
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Sirius launch new Analytical Services
In recognition of the rapidly growing trend for outsourcing of PhysChem measurements across the pharmaceutical and biotech industry, we have expanded and re-structured our Analytical Service offering. Our new analytical service provides a reliable source of cost effective and expert outsourcing for PhysChem measurements at three broad stages of the drug discovery and development process.
See our Analytical Service pages for more details
Sirius launch new website.
After a major redesign we are proud to launch our new website, which offers improved functionality for our visitors and easier access to relevant information on our services and products.
Sirius goes direct in Austria, Belgium, Germany, Netherlands and Switzerland.
We are now dealing directly from Sirius in the UK with all customers in Austria, Belgium, Germany, Netherlands and Switzerland. This action will allow us to provide first class technical, sales and service support, efficiently and quickly. Contact us now for help in these territories.
Sirius in North America.
Due to our rapidly growing business we have upgraded and moved to a larger facility allowing us to serve you better. This move will give us the necessary space to build our new technical support and instrumentation laboratories, provide us with larger facilities for instrument repair and spare parts inventory and increase our administration spaces for our expanding group. Our new office is located in the Lakewood Industrial Park in Lakewood, NJ near the beautiful Jersey Shore. Effective immediately all correspondence, orders, products and services for our North American customers will be processed through the new office. Click here for our new US office address.
Sirius goes direct for GLpKa in Sweden and Finland.
We are now dealing directly from Sirius in the UK with GLpKa, PCA200 and D-PAS customers in Sweden and Finland. This action will allow us to provide first class technical, sales and service support, efficiently and quickly. Contact us now for help in these territories.