At Sirius Analytical we design and manufacture highly automated instruments to measure physicochemical parameters - pKa, logP & logD, solubility and dissolution. We also operate as a CRO providing a wide range of physical chemistry analytical services.
2009 saw strong sales of the new SiriusT3 instrument, with many customers upgrading from the old GLpKa platform. Another significant area of growth was seen in our CRO services, which have seen increasing demand as big pharma strives to reduce headcounts and increase efficiency. Our GI Dissolution module for SiriusT3 opened up a new area of research, with Dissolution in biorelevant media a hot topic across the industry. We successfully relocated our US operations to Beverly, MA, which places us in a superb location to support our expanding base of US customers.
2008 started with a major challenge for Sirius, with a large fire at our UK headquarters causing significant damage to our offices and forcing us to relocate to temporary facilities for the first half of the year. Despite this major setback (which would have resulted in the closure of many companies) we fought hard to maintain our levels of service, sales and product development with minimal disruption for our customers. After 6 months in cramped temporary conditions we were able to relocate back into our newly repaired and refurbished headquarters. The year ended in great success with the launch of our SiriusT3 system, the culmination of many years of research work to miniaturize the components of the GLpKa system and create a new platform for the next generation of assay development from Sirius.
A notable year for publications with Sirius authors, including two papers about MDM solvent, two papers about polymorphism and five posters at the AAPS Annual Meeting in San Diego.
Sirius develops Vinotrate, a new instrument for a new market. Based on our titration and pH technology, Vinotrate was designed for measuring pH and titratable acidity of wine and fruit juices. Electronics and software are completely new. A strong customer base was quickly established in Southern California.
Sirius Analytical Inc. opens in Piscataway, NJ. Significant advances in CheqSol research; Chasers vs non-chasers, solubility at 37°C, evidence for changes in crystalline form discovered. First CheqSol solubility paper published.
Significant growth in the Analytical Service business which reflects the value of measured physicochemical properties in ADME decision-making. Sirius sponsored a successful LogP2004 meeting in Zurich, where we exhibited four posters concerning our latest research, including our new MDM cosolvent method, and work to show correlations between measured PAMPA permeability and logP dodecane-water. In April, we discovered a remarkable new way to measure intrinsic solubility of ionisable compounds by automated potentiometric titration. By September, we launched CheqSol Solubility software for RefinementPro2, as well as FastD-PAS for high throughput UV pKa measurement on GLpKa + D-PAS, generating a substantial amount of interest. After several years of collaboration, Sirius and pION Inc. decided to go their separate ways. The latter part of the year saw Sirius preparing for the launch of Sirius Analytical Inc. In preparation, we had our first independent exhibition booth at AAPS in Baltimore in November 2004.
Launch of the ProfilerLDA for high throughput logD measurement.
Major refurbishment of Riverside, our corporate headquarters in Forest Row, UK, to give two new laboratories, enlarged production facilities and training suite. The Fourth Users' Meeting is held in Brighton, UK.
Sirius sells the first PSR4 permeability measurement system in Europe.
