Analytical Service

lba2

Overview

Sirius analytical service provides a reliable and cost-effective source of outsourcing for PhysChem measurements at three broad stages of the drug discovery and development process.

Medicinal Chemistry & Hit to Lead.

Pre-formulation.

Formulation & Development.

For each sector our portfolio of services is designed to provide optimum levels of information, reliability and turnaround

Since 1991 we have provided an analytical service to our customers, during which time thousands of compounds have been measured for a wide range of PhysChem properties.

Our experienced chemists provide the highest quality service using state-of-the-art instrumentation. We work with our clients to ensure the most applicable analytical protocol is used. All analyses are fully confidential.

All work is carried out under strictly controlled conditions, and comprehensive analysis reports are provided . All calibrations and reagent standardisations are recorded. Assay results are quoted with reference to all relevant calibrations, standardisations, instrument identification and operator identification. All relevant documentation is available for audit.

To use the Analytical Service, select the assay from the relevant area on the left, complete the relevant sample registration form and send it to us with your samples. If required, please send your Confidentiality Agreement in advance for signature and filing.

Back to top

Standard Assay conditions

Where applicable, our standard assay conditions are:

Temperature 25°C
Ionic strength background 0.15M potassium chloride
CoSolvents methanol, dioxane, dimethyl sulfoxide
Partition solvent octan-1-ol
Standard screening pH pH7.4

For the screening services, samples should be 10mM DMSO solutions.

Alternate conditions are supported, however a surcharge may be made to cover the additional work required.

Back to top

Custom Analysis

Our flexible titration based instruments can be applied to other areas of research, including:

Dissolution & Precipitation rates
Polymorphism
Salt Solubility
pKa, logP and Solubility studies at different temperatures
Stability
Solubility in Excipients
Supersaturation experiments
Liposome partitioning
Compound behaviour in 100% organic solvents
Protonation of peptides and macromolecules
Determination of isoelectric point
pH stat
Metal binding

Please contact us for more information.

How we use your details Back to top
Latest news

New Vacancy at Sirius - Applications Chemist

28.5.08

Sirius are seeking a new Applications Chemist to join our team

Read more

Sirius launch expanded Analytical Service

01.7.08

New PhysChem assays and services now available

Read more

Coming events

ADMET: A focus on drug discovery

01.7.08

John Comer and Karl Box from Sirius are presenting the pre-conference workshop at this exciting event.

Read more

BPC 2008

09.9.08

John Comer from Sirius is giving a presentation on solubility and supersaturation, and their effects on predicting oral absorption

Read more

Main site navigation
HOME
PRODUCTS
INSTRUMENTATION
GLpKa
D-PAS
PCA200
CheqSol
Fast D-PAS
Electrodes
Profiler SGA
GLpH
Vinotrate
SOFTWARE
RefinementPro 2
ADME Boxes
ANALYTICAL SERVICE
Medicinal Chemistry &    Hit to Lead
Preformulation
Formulation and Development
Consultancy
SERVICE AND SUPPORT
Maintenance
Service
Technical support
Material Safety Datasheets
Certificates of conformity
Electrode warranty forms
SCIENCE
PhysChem
pKa
logP
Solubility
Wine chemistry
TRAINING
Training sub menu
On-line training
In house training
Training courses in USA
Training courses in the UK
LITERATURE
Literature sub menu
Brochures
Bibliography
Posters
Slides
CONTACT
ABOUT
History
News archive
Events archive