At Sirius Analytical we design and manufacture highly automated instruments to measure physicochemical parameters - pKa, logP & logD, solubility and dissolution. We also operate as a CRO providing a wide range of physical chemistry analytical services.
The PhysChem Forum Committee have announced their 12th Physical Chemistry Forum will be held at the Hungarian Academy of Sciences (HAS), Main building, Budapest, Hungary on Thursday 19th April 2012.
This symposium will have the themes: design of lead molecules with more appropriate physico-chemical properties; models of gastro-intestinal absorption; special issues of solubility and dissolution measurements and new applications of PAMPA method.
For full details of the meeting please visit the PhysChem Forum website.
Sirius Analytical will be attending the Global Formulation and Drug Delivery Summit on the 16 - 18 April, 2012 in Amsterdam, Netherlands.
The summit will present focused and detailed presentations of innovative pharmaceutical research and real life case studies from senior level formulation and drug delivery experts.
With two dedicated streams, interactive round table discussions and pre-conference workshops, the event will create an unrivalled opportunity for advancement in this field.
Brendan Griffin, University of Cork, talks on advancements in Lipid Based Formulations.
Dr. Norbert Rasenack, Novartis Pharma, talks about the opportunities of Continuous Manufacturing to improve drug development.
To read more about these key discussion areas and for more information on the summit, please visit the conference website.
Sirius Analytical Inc. will be attending and exhibiting at the 6th Improving Solubility Conference on March 28 - 30, 2012, at Loews Philadelphia Hotel, Philadelphia, PA.
The 6th Improving Solubility Conference will provide you with immediate takeways from 3 days of in-depth case studies and discussions of how to effectively improve drug candidate solubility and bioavailability.
Poorly soluble compounds represent over 60% of compounds in drug development and this figure is continuing to increase as technologies become more complex. Learn the latest methodologies and technologies to take on this challenge and minimize the time-to-market on your drug pipeline.
The programme will include the following:
Utilize solid dispersion processes during our half-day devoted to amorphous formulation
Predict absorption of new chemical entities within silico modeling
Utilize Pharmaceutical Co-Crystals to enhance solubility and dissolution of insoluble APIs
Maximize the systematic exposure of drugs in toxicology evaluations and early formulation
Enhance the bioavailability of poorly soluble compounds using lipid-based formulations
Investigate strategies to maintain your patent life-cycle
For more information please visit the conference website.
Sirius Analytical will be exhibiting and attending at the 8th World Meeting on Pharmaceutics Biopharmaceutics and Pharmaceutical Technology on 19th to 22nd March 2012 in Istanbul, Turkey.
Lecture topics will include:
• Quality by Design/PAT
• Continuous Production
• Industrial Scale Production of Smallest Batches
• Vaccine Development/Therapeutic Vaccination
• Innovative Parenteral Preparations
• Counterfeiting of Drugs and Drug Products
• Dosage Forms for Paediatrics and Geriatrics
• Oral Products for Poorly Water Soluble Drugs
• Polymeric Excipients for Oral and Parenteral Applications
• Orphan Application Sites for Drugs: Ear, Nose, Eye
• Therapeutic Protein Modifications and Biological Relevance
• Drug Regulatory Affairs
• Solid dosage forms
• Dissolution Testing/Quality Control
Fro more informaiton on the meeting please visit PBP World Meeting.
Sirius Analytical's Chief Scientific Officer, John Comer, will be presenting on the Formulation & Solubility track at the Discovery Chemistry Congress on the 13-14 March 2012 in Munich, Germany.
Agenda topics include:
Formulation strategies
Identifying ways of improving drug solubility
Modifying solubility of drug compounds
Optimisation of bioavailability through formulation
Pre-formulation studies
Toxicology studies of enhanced solubility compounds
For more information on the meeting please visit SelectBiosciences.
Sirius Analytical Inc. presents and sponsors at ExL Pharma’s Enhancing Bioavailability Conference on January 25th-26th 2012 at Omni Parker House Hotel, Boston, MA.
John Comer (CSO, Sirius Analytical Inc.) will discuss Investigating and Modifying the Extent and Duration of Supersaturation of Ionizable Drugs including solubility measurement using titration with mass and charge balance analysis, cocrystal formation using titration-based solubility measurement and uncontrolled versus controlled supersaturation.
ExL Pharma's Enhancing Drug Bioavailability and Solubility Conference will assist you in adopting novel formulation approaches to maximize time-to-market, as well as discover the latest strategies for a successful drug development pipeline. This intensive 2-Day program will enable YOU to gain novel drug solubility strategies, which will benefit your current and future pipelines. This training course will provide you with unique take-home examples, case studies and multiple formulation and preformulation strategies to assist in improving drug solubility and bioavailability, maximizing exposure, and increasing time-to-market.
What else is being discussed?
• Pharmaceutical formulation development strategies for successful product development
• Maximizing exposure for new compounds in early formulation development
• Product diversification and enhancement through pre-formulation technologies
• Solution behavior of amorphous solid dispersions and their bioavailability implications
• Examining if cocrystal solubility in biorelevant media can be predicted
• Expedited formulation development guided by biopharmaceutical modeling
• Characterization, design and development of super saturation based drug delivery
• Solubilization approaches for parenteral routes of administration
Sirius Analytical will be exhibiting and attending at the 3rd Annual World Drug Delivery and Formulation Summit 2012 on 16th-18th January 2012 at the Maritim ProArte Hotel Berlin, Germany.
Karl Box, Sirius Head of R&D will speak on the subject:
'Experimental Methods for Investigating and Modifying Supersaturation to Enhance Drug Bioavailability'.
The talk will discuss:
The use of supersaturation to increase bioavailability of drugs for GI absorption
Fast experimental techniques for assessing the extent and duration of supersaturation
How supersaturation can be enhanced using additives and excipients
GI Dissolution assays for exposing small pellets of API to changing pH conditions and lipids to simulate passage of drugs through the GI tract.
Sirius Analytical will be exhibiting and attending at the Joint Pharmaceutical Analysis Group meeting 'Predictive tools in the development of solid oral dosage forms' on Thursday 8th December 2011 at the Royal Astronomical Society, Burlington House, London.
Predictive modelling approaches are demonstrating increasing value throughout the product development cycle, from the prediction of physiochemical properties of potential drug candidates in discovery, through the prediction of product characteristics and performance during clinical development, to the understanding of powder behaviour during large-scale manufacture.
This one-day symposium will explore how predictive tools can be used to accelerate and reduce the risk of development of solid oral dosage forms and obtain maximum value from analytical measurements.
Speakers:
Dr David Elder, GSK, Stevenage, UK
Dr Marcus Brewster, Johnson & Johnson, Belgium
Martin Ott, Lhasa Limited, UK
Garry Scrivens, Pfizer, Sandwich, UK
Dr Nikoletta Fotaki, University of Bath
Dr. Chan-yu Wu , University of Birmingham
Sirius Analytical will be exhibiting and attending the 2011 Drug Delivery and formulation Asia Summit on December 6th-7th, 2011 in Shanghai, China.
Karl Box, Research & Development Manager at Sirius Analytical, will present during this session with a talk entitled 'Techniques for investigating supersaturation and the enhancement of solubility'.
Sirius Analytical will be exhibiting and attending the 2011 Eastern Analytical Symposium and Exposition on November 14-17, 2011 at the Garden State Exhibit Center, Somerset, New Jersey, US.
Eastern Analytical Symposium and Exposition (EAS) is the world's leading community for analytical chemists seeking the highest quality education and career development.
Sirius Analytical will be exhibiting and attending the 2011 AAPS Annual meeting and Exposition on October 23-27, 2011 at the Walter E. Washington Convention Center, Washington, DC, USA. Visit us in booth number 229.
Karl Box, Research & Development Manager at Sirius Analytical, will present during this session with a talk entitled 'Experimental Methods for Investigating Drug Supersaturation Behaviour'.
Sirius Analytical invites you to attend a free webinar on Thursday, August 18, 2011 10.00am - 11.00am EDT.
It will be presented by John Comer, Technical Director, entitled 'Small-Scale Dissolution Measurements using Pure API - a useful way to investigate drug-excipient interactions under biologically relevant conditions'.
Click here to reserve your place. Detailed instructions on how to log in and participate in the webinar will provided upon registration.
The webinar will be available as a download from the website shortly after the event has finished.
