Sirius Scientific Posters
Because it takes time for new analytical methods to appear in scientific papers, the most up-to-date descriptions of our technology are in posters at scientific meetings. Recent topics include LogP vs. LogS as a way to predict BCS class, and related work comparing LogP vs. PAMPA, as well as our work on Polymorph Creation using CheqSol, a new assay for Precipitation Rates and work on Measuring pKa in Non-Aqueous Solvents, a topic of increasing interest in pharmaceutical manufacturing and scale-up.
Posters - LogP2009
Measuring supersaturation and enhanced solubility of a low solubility drug in the presence of excipients: an opportunity to promote a compound's BCS class.
A method for assessing dissolution, supersaturation and precipitation of a drug during passage through the gastro-intestinal tract
Rapid solubility measurement with full automation using low sample weights
Rapid Surface Acitivy Measurement
Fast pKa screening using 3無 of 10mM DMSO stock
Stable, purified P-gp promises high throughput, interference-free assays
Posters - AAPS November 2008
Measuring supersaturation and enhanced solubility of a low solubility drug in the presence of excipients: an opportunity to promote a compound's BCS class.
A method for assessing dissolution, supersaturation and precipitation of a drug during passage through the gastro-intestinal tract.
Rapid solubility measurement with full automation using low sample weights
pKa measurement using 50無 to 100無 aliquots from DMSO stock, no chromophore required
Fast pKa screening starting from 3無 of 10mM DMSO stock
Stable, purified P-gp promises high throughput, interference-free assays
Posters - AAPS November 2007
Determining Stoichiometry of TFA counter-ions
LogP, logS and biopharmaceutics classification
Henderson Hasselbalch and solubility
New assay for precipitation rates
Polymorph Creation using CheqSol
Posters - AAPS October 2006
Thyroxine and glipizide pKa measurement by Fast D-PAS
Real time polymorph conversion
Posters - AAPS Critical Issues April 2006
Fast pKa measurement for poorly soluble molecules
Effect of supersaturation on solubility measurements
Posters - User Meeting April 2005
Analytical Service
CheqSol
LogP dodecane-water v PAMPA
pKa of bases in MDM-water
High throughput pKa measurement
Latest Sirius Posters Available for download
01.08.09
Our latest posters, including Solubility & Dissolution measurements in excipients and FaSSIF/FeSSIF media and high throughput pKa measurements, are available for download.
New Scientific Paper Published
07.12.09
New paper from Sirius explains how our solubility measurements work, and introduces new methods for evaluating supersaturation.
PhysChem Forum 8
23.03.10
Sirius are sponsors and exhibitors at the next PhysChem Forum being held at Pfizer in Sandwich, UK.
ADMET Europe 2010
08.04.10
Sirius will be exhibiting and speaking at ADMET Europe 2010 in Munich. Visit us on booth #12.