Sirius Analytical Products

Accurate pK_a, logP/D and solubility measurement

The SiriusT3 is a complete and fully automated system for accurate measurement of ionization, lipophilicity and solubility by pH-metric and UV methods using sub-mg quantities of material.

High throughput pK_a measurement

SiriusT3 can be used to measure pK_as in high throughput mode, requiring just a single 3µl aliquot of 10mM DMSO stock and approximately 4 minutes per measurement to give a full 40 point titration curve with in-situ UV spectroscopic measurement (220 to 700nm each point).

For existing GLpKa/PCA200/D-PAS users - upgrade to Fast D-PAS to measure a batch of 50 samples for pK_a in just four hours.

Detailed solubility and supersaturation measurement

SiriusT3 features our unique CheqSol technology as standard, enabling real-time dynamic measurement of both kinetic and thermodynamic solubility and also investigation of supersaturation, precipitation rates and polymorphism.

For existing GLpKa/PCA200/D-PAS users - upgrade to Solubility for accurate solubility measurement of ionizable compounds by Sirius pH-metric methods.

Dissolution measurement with pH control

Use our GI Dissolution assay for investigation of Dissolution profiles at physiologically relevant pH conditions and in the presence of buffers, excipients and simulated intestinal fluids (FaSSIF/FeSSIF) using just a few milligrams of drug.

Surface Tension, CMC and Phospholipidosis Measurement

Use the Kibron Delta-8 Instrument for high throughput, precise measurement of surface tension, critical micelle concentration, and phospholipidosis risk prediction.

Instruments for pH and acidity QC

Use our GLpH instrument for accurate, automated pH measurement of pharmaceuticals, vaccines and other pH-critical products, and Vinotrate for pH and total acidity (TA) measurement of wine and juices.