At Sirius Analytical we design and manufacture highly automated instruments to measure physicochemical parameters - pKa, logP & logD, solubility and dissolution. We also operate as a CRO providing a wide range of physical chemistry analytical services.
Multichannel Microtensiometer for high throughput surface activity profiling
The Delta-8 instrument is a fully automated, multichannel tensiometer with 8 parallel balances that measure surface tension.
By measuring Surface Tension at a range of different drug concentration values a CMC profile can be obtained in just minutes:
Automatic cleaning of the probes with the integrated DyneClean prior to each measurement cycle reduces maintenance and enables automation. The specialized 96-well plates, DynePlate, that make the measurement affordable due to reduced sample consumption and labor time.
The Delta-8 system can be easily integrated into conventional laboratory robotics due to the standard footprint 96-well plate.
By making CMC measurements in the presence of a phospholipid complex it is easy to screen drugs for the risk of induced phospholipidosis using the Delta-8 system.
Screening new drugs for the risk of induced Phospholipidosis at an early stage can avoid the potential for late stage costly modifications or even market withdrawal.
Sirius Analytical are exclusive distributors of the Kibron Delta-8 instrument to the pharmaceutical industry in the UK, USA and Canada.
