18-30ºC
Delta-8 - Multichannel Microtensiometer
Overview
For high throughput surface activity profiling and phospholipidosis risk prediction
- Surface Tension
- Critical Micelle Concentration
- Total Surface Area
- Air/Water partition co-efficient
- Kibron PLDscreen - for prediction of drug induced phospholipidosis
- 8 parallel high-precision microbalances
- Measure a 96 well plate in under 20 minutes
- Automatic probe cleaning after each assay
- Easy integration to automatic liquid handling systems
The Delta-8 instrument is a fully automated, multichannel tensiometer with 8 parallel balances that measure surface tension.
The instrument uses small needles, DyneProbes that are inexpensive and robust compared to Wilhelmy plates and Du Nuoy rings.
Automatic cleaning of the probes with the integrated DyneClean prior to each measurement cycle reduces maintenance and enables automation. The specialized 96-well plates, DynePlate, that make the measurement affordable due to reduced sample consumption and labor time.
The Delta-8 system can be easily integrated into conventional laboratory robotics due to the standard footprint 96-well plate.
Screening new drugs for the risk of induced Phospholipidosis at an early stage can avoid the potential for late stage costly modifications or even market withdrawal.
Sirius Analytical are exclusive distributors of the Kibron Delta-8 instrument to the pharmaceutical industry in the UK, USA and Canada.
Delta-8 Video
This video shows an introduction to the Delta-8 system and its applications
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Technical specificiation
Temperature Range
Measurement volume
50 µl/well
Surface tension range
10 - 100 mN/m
Resolution
0.01 mN/m
Method
Maximum pull force/du Nouy
Measurement time (96-well plate)
ca. 3-20 minutes
DyneProbe lifetime
100 burns
DyneProbe cleaning
Heating in a DyneClean furnace
DyneClean lifetime
400 burns
DynePlate Dimensions
127.8×85.5 mm (standard footprint)
DynePlate Volume
50µl / well
DynePlate Type
Disposable
Operating systems
Win98/NT4.0/2000/XP
Minimum PC requirements
PII266 MHz, 64 MB memory, CD-ROM drive, SVGA display, one free COM-port, 25 MB disk space
Physical dimensions - Weight
24 kg (75lb. Max)
Physical dimensions - Height
405 mm
Physical dimensions - Width
770 mm
Physical dimensions - Depth
>370 mm
Power Supply - Input
100-120/200-240 V, 47-63 Hz.
Power Supply - Output
12 V DC, 10.8 A.
Power Supply - Max
120W
Latest product news
Phospholipidosis lecture at Miptec 2008
Our colleagues from Kibron presented a lecture on Phospholipidosis screening using the Delta-8 at this meeting. More details are available on the Miptec website.
Added: 2008
Phospholipidosis measurement with Delta-8
PLDscreen - a fast screen for unparalleled prediction of risk for drug-induced phospholipidosis.
Phospholipidosis (PLD), the accumulation of phospholipids in tissues such as lungs, kidneys and liver, has been recognized to represent a potential causative process for a number of serious side effects, particularly for drugs intended for long term usage by the patients. Consequently, it is desirable to identify potential PLD inducing compounds at an early drug development stage, such as lead optimization.
The reason for PLD is believed to be the formation of drug-phospholipid complexes, which cannot be metabolized by phospholipid-degrading enzymes, phospholipases.
The issue of phospholipidosis has garned sufficient concern for the FDA to establish a working group in 2004 to investigate the problem and develop recommendations for drug developers.
Kibron PLDscreen (Phospholipidosis screen) is a robust in vitro HTS assay which measures directly the strength of drug-phospholipid interaction. More specifically, it detects the drug-induced shift in the critical micelle concentration (CMC) for a phospholipid, measured using the Delta-8 surface tension plate reader.
PLDscreen predicts with unparalleled accuracy the ability of compounds to induce PLD. This proprietary assay allows for high throughput screening of molecules with minimal compound consumption, hundreds of compounds in a single working day!
The PLDscreen comprises of the Kibron Delta-8 surface tension plate reader, PLDscreen software, PLDnanosol reagent, and DyneSearch microtiter plates.
Added: 2008
Literature
Electronic copies of the Delta-8 brochure and technical specifications are available for download:
> Delta-8 Brochure> Delta-8 Technical Specifications
Sirius appointed as distributors for Kibron Delta-8
24.7.08
Sirius are now the exclusive distributors in UK, USA and Canada for the Kibron Delta-8 system for measurement of surface tension and phospholipidosis.
Cambridge scientists set solubility challenge
11.8.08
A new paper from scientists using Sirius solubility techniques at the University of Cambridge asks "can you predict solubilities of 32 molecules using a database of 100 reliable measurements?".
AAPS Annual Meeting
16.11.08
Sirius will have a booth (#1460) at this years AAPS Annual Meeting in Atlanta, Georgia.