Top navigation: HOME; SITE MAP

Delta-8 - Surface Activity, Phospholipidosis

Page menu: Overview; Delta-8 Videos; Technical specification; Latest product news; Literature

Overview

Multichannel Microtensiometer for high throughput surface activity profiling

Surface Tension
Critical Micelle Concentration
Total Surface Area
Air/Water partition co-efficient
Kibron PLDscreen - screening for drug induced phospholipidosis
8 parallel high-precision microbalances
Measure a 96 well plate in under 20 minutes
Automatic probe cleaning after each assay
Easy integration to automatic liquid handling systems

The Delta-8 instrument is a fully automated, multichannel tensiometer with 8 parallel balances that measure surface tension.

By measuring Surface Tension at a range of different drug concentration values a CMC profile can be obtained in just minutes:

Automatic cleaning of the probes with the integrated DyneClean prior to each measurement cycle reduces maintenance and enables automation. The specialized 96-well plates, DynePlate, that make the measurement affordable due to reduced sample consumption and labor time.

The Delta-8 system can be easily integrated into conventional laboratory robotics due to the standard footprint 96-well plate.

By making CMC measurements in the presence of a phospholipid complex it is easy to screen drugs for the risk of induced phospholipidosis using the Delta-8 system.

Screening new drugs for the risk of induced Phospholipidosis at an early stage can avoid the potential for late stage costly modifications or even market withdrawal.

Sirius Analytical are exclusive distributors of the Kibron Delta-8 instrument to the pharmaceutical industry in the UK, USA and Canada.

Delta-8 Overview Video

This video shows an introduction to the Delta-8 system and its applications

Click here to download the hi-res video (31.0Mb)

Phospholipidosis

This video shows the use of the Delta-8 system to measure the risk of drug induced phospholipidosis

Click here to download the hi-res video (27.4Mb)

Technical specification

Temperature Range

18-30ºC

Measurement volume

50 µl/well

Surface tension range

10 - 100 mN/m

Resolution

0.01 mN/m

Method

Maximum pull force/du Nouy

Measurement time (96-well plate)

ca. 3-20 minutes

DyneProbe lifetime

100 burns

DyneProbe cleaning

Heating in a DyneClean furnace

DyneClean lifetime

400 burns

DynePlate Dimensions

127.8×85.5 mm (standard footprint)

DynePlate Volume

50µl / well

DynePlate Type

Disposable

Operating systems

Win98/NT4.0/2000/XP

Minimum PC requirements

PII266 MHz, 64 MB memory, CD-ROM drive, SVGA display, one free COM-port, 25 MB disk space

Physical dimensions - Weight

24 kg (75lb. Max)

Physical dimensions - Height

405 mm

Physical dimensions - Width

770 mm

Physical dimensions - Depth

>370 mm

Power Supply - Input

100-120/200-240 V, 47-63 Hz.

Power Supply - Output

12 V DC, 10.8 A.

Power Supply - Max

120W

Latest product news

Phospholipidosis lecture at Miptec 2008

Our colleagues from Kibron are presenting a lecture on Phospholipidosis screening using the Delta-8 at this meeting. More details are available on the Miptec website.
Added: 2008

Phospholipidosis measurement with Delta-8

PLDscreen - a fast screen for unparalleled prediction of risk for drug-induced phospholipidosis.

Phospholipidosis (PLD), the accumulation of phospholipids in tissues such as lungs, kidneys and liver, has been recognized to represent a potential causative process for a number of serious side effects, particularly for drugs intended for long term usage by the patients. Consequently, it is desirable to identify potential PLD inducing compounds at an early drug development stage, such as lead optimization.

The reason for PLD is believed to be the formation of drug-phospholipid complexes, which cannot be metabolized by phospholipid-degrading enzymes, phospholipases.

Kibron PLDscreen is a robust in vitro HTS assay which measures directly the strength of drug-phospholipid interaction. More specifically, it detects the drug-induced shift in the critical micelle concentration (CMC) for a phospholipid, measured using the Delta-8 surface tension plate reader.

PLDscreen predicts with unparalleled accuracy the ability of compounds to induce PLD. This proprietary assay allows for high throughput screening of molecules with minimal compound consumption, hundreds of compounds in a single working day! The PLDscreen comprises of the Kibron Delta-8 surface tension plate reader, PLDscreen software, PLDnanosol reagent, and DyneSearch microtiter plates.
Added: 2008