Fast D-PAS - high throughput pK_a assay

Overview

High throughput pK_a measurement on GLpKa and PCA200 with D-PAS

• Fast hybrid pH/UV method saves time
• Only 4 minutes per sample!
• Easy assay set-up
• Highly automated
• pKas between 2 and 12
• Up to 50 samples in four hours
• Accurate, repeatable results
• Aqueous and cosolvent methods

Fast D-PAS is an upgrade for GLpKa and PCA200 with D-PAS. Fast D-PAS will enable you to measure pK_a values very quickly with no loss in data quality.

Titrations are performed in the presence of a unique linear buffer solution. This buffer solution allows the pH electrode to reach a stable value very quickly after each addition of titrant.

Fast D-PAS measures pK_a for water-soluble samples in just four minutes. Water-insoluble samples are measured in water-solvent mixtures using a multiple titration.

It takes less than 10 minutes to do a 3-titration assay over a range of pH 2 to 12, covering a range of cosolvent dilution, say from 50% to 30%. A Yasuda-Shedlovsky extrapolation to the aqueous pK_a is plotted automatically.

Reference spectra for Fast D-PAS experiments are obtained from a Buffer Calibration titration. In this procedure, a blank solution is titrated over the full pH range, and the UV spectra are saved after each addition of titrant. This procedure provides reference spectra of the highest quality and only needs to be performed once per day.

Literature

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Certificates of Conformity

Material Safety Data Sheets