Fast D-PAS - high throughput pKa assay
Overview
High throughput pKa measurement on GLpKa and PCA200 with D-PAS
- Fast hybrid pH/UV method saves time
- Only 4 minutes per sample!
- Easy assay set-up
- Highly automated
- pKas between 2 and 12
- Up to 50 samples in four hours
- Accurate, repeatable results
- Aqueous and cosolvent methods
Fast D-PAS is an upgrade for GLpKa and PCA200 with D-PAS. Fast D-PAS will enable you to measure pKa values very quickly with no loss in data quality.
Titrations are performed in the presence of a unique linear buffer solution. This buffer solution allows the pH electrode to reach a stable value very quickly after each addition of titrant.
Fast D-PAS measures pKa for water-soluble samples in just four minutes. Water-insoluble samples are measured in water-solvent mixtures using a multiple titration.
It takes less than 10 minutes to do a 3-titration assay over a range of pH 2 to 12, covering a range of cosolvent dilution, say from 50% to 30%. A Yasuda-Shedlovsky extrapolation to the aqueous pKa is plotted automatically.
Reference spectra for Fast D-PAS experiments are obtained from a Buffer Calibration titration. In this procedure, a blank solution is titrated over the full pH range, and the UV spectra are saved after each addition of titrant. This procedure provides reference spectra of the highest quality and only needs to be performed once per day.
Latest Sirius Posters Available for download
01.08.09
Our latest posters, including Solubility & Dissolution measurements in excipients and FaSSIF/FeSSIF media and high throughput pKa measurements, are available for download.
New Scientific Paper Published
07.12.09
New paper from Sirius explains how our solubility measurements work, and introduces new methods for evaluating supersaturation.
PhysChem Forum 8
23.03.10
Sirius are sponsors and exhibitors at the next PhysChem Forum being held at Pfizer in Sandwich, UK.
ADMET Europe 2010
08.04.10
Sirius will be exhibiting and speaking at ADMET Europe 2010 in Munich. Visit us on booth #12.