Fast D-PAS - high throughput pKa assay

Fast D-PAS

Overview

High throughput pKa measurement on SiriusT3

  • Fast hybrid pH/UV method saves time
  • Only 4 minutes per sample!
  • Easy assay set-up
  • Highly automated
  • pKas between 2 and 12
  • Up to 50 samples in four hours
  • Accurate, repeatable results
  • Aqueous and cosolvent methods

Fast D-PAS UV pKa screening allows fast pKa measurement with no loss in data quality.

Titrations are performed in the presence of a unique linear buffer solution. This buffer solution allows the pH electrode to reach a stable value very quickly after each addition of titrant.

Fast D-PAS UV pKa measures pKa for water-soluble samples in just four minutes. Water-insoluble samples are measured in water-solvent mixtures using a multiple titration.

It takes less than 10 minutes to do a 3-titration assay over a range of pH 2 to 12, covering a range of cosolvent dilution, say from 50% to 30%. A Yasuda-Shedlovsky extrapolation to the aqueous pKa is plotted automatically.

Reference spectra for Fast D-PAS UV pKa experiments are obtained from a Buffer Calibration titration. In this procedure, a blank solution is titrated over the full pH range, and the UV spectra are saved after each addition of titrant. This procedure provides reference spectra of the highest quality and only needs to be performed once per day.

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Literature

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Certificates of Conformity

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Material Safety Data Sheets

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New Scientific Paper Published

07.12.09

New paper from Sirius explains how our solubility measurements work, and introduces new methods for evaluating supersaturation.

Read more

New Scientific Paper Published

01.07.10

New paper - Study of pH-dependent solubility of organic bases. Revisit of Henderson-Hasselbalch relationship.

Read more

ACS Fall 2010 National Meeting, Boston

22.08.10

Sirius will exhibit at this meeting.

Read more

Physchem Forum 9, Barcelona

17.09.10

Sirius will exhibit at and sponsor the next Physchem Forum meeting in Barcelona

Read more

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