Sirius Insight - Particle Size and Shape Analyser
Particle size is a key physical property for many materials which has an important impact on product and process performance. For pharmaceuticals, the particle size of the active pharmaceutical ingredient and excipients can affect bioavailability, stability and the ability to process and manufacture a product. Particle size is often a critical quality attribute controlled by a compound specification.
The measurement of particle size can be a significant analytical challenge during drug development to ensure that results are meaningful and enable the effective control of product and process. The analytical approach taken must ensure suitable dispersion of the sample and utilise an effective measurement technique to deliver an accurate and reproducible particle size distribution.
The new Sirius Insight is an innovative particle size analyser which makes particle size measurements easier, more meaningful and robust. The instrument utilises two measurement methods: Laser Obscuration Time (LOT) and digital video imaging. This dual channel approach enables the measurement of particle size using the LOT technique and provides a large number of particle shape parameters through dynamic image analysis. The LOT method possesses many advantages as a sizing technique:
- LOT is independent of optical properties and makes no assumptions about the particles being measured (e.g. shape or refractive index). This makes it very suitable for making accurate size measurements on samples which are either single compounds or mixtures of compounds such as drug-excipient blends.
- It is not a volume based measurement, so it can be used effectively for polydispersed samples or samples and samples with minor size fractions.
- LOT is a time-domain measurement, making it suitable for solids concentration measurements.
- Dual channel detection gives high information content: the video channel enables the determination of a number of particle shape parameters. This powerful feature enables material behaviour to be correlated with particle properties other than size.