PCA200 - entry level pKa & logP titrator

Please note: We have discontinued production of new PCA200 systems due to the launch of its successor, the new SiriusT3.

Service and support for existing PCA200 customers will remain available until further notice.

Overview

Low cost auto titrator for entry level automation of pKa, logP/D, Solubility and Dissolution measurement

  • pH-metric pKa, logP and logD
  • pH range of 1.8 - 12.2 (for standard titrations)
  • Fully automated probe movement, washing and calibration
  • Built-in cosolvent methods for poorly soluble drugs
  • Automatic results processing and QC checks
  • Built-in traceability and maintenance reminders
  • Temperature controlled sample position

PCA200 was a semi-automated instrument for high-quality measurement - Ideal for laboratories with a low sample throughput, or for academic research applications.

pKa is measured by automated potentiometric titration. LogP is also measured by a potentiometic method, based on a two-phase acid- base titration in a mixture of water and octanol.

Back to top

specification

pH electrodes

Ag/AgCI, double junction reference

Stirrer

Overhead, variable speed

Temperature probe

PT100, allows automatic temperature compensation

Precision dispensers

Acid and Base, minimum of 0.4µL with 5mL syringe

DualTip dispenser

Two quartz dispenser tubes

Probe movement

Fully automated X-Y axis

Washes

Two water washes and one special wash station provided

Electrode storage/calibration

Two pH7 buffer positions, one storage and one calibration

Single sample holder

Glass temperature control vessel (external circulating bath required)

Purge gas

Nitrogen or argon required

Partition solvents

Supports 7 including Octanol and a generic solvent

CoSolvents

Supports 10 including MeOH and DMSO

Keypad

Liquid-crystal 16-line display for text and graphics, 22-buttons for numeric data entry

System standardisation

Sirius Four-Plus(TM) procedure

Sample concentration

>0.5 mM (depending on the pH range)

pH-range

1.8 - 12.2

Assay volume

Minimum 5mL, maximum 20mL

Spectroscopy

Supports D-PAS

Services required

One mains power inlet (110 or 240 V)

Connection to the PC

Cable from PCA200 to PC serial comm port

Computer

Windows 2000 or XP

Software

PCA200 Firmware Version 2.107. RefinementPro Version 2.0.1.1

Reagent requirements

See 'pH-metric reagents' sheet

Dimension

600 x 440 x 520mm (WxDxH)

Weight of unit

25kg

Dimensions of packaging

900 x 800 x 750mm (WxDxH)

Weight of packed unit

Back to top

Literature

Electronic copies of our PCA200 brochure and technical specifications are available for download:

> PCA200 Brochure
> PCA200 Techinical Specifications
Back to top

New Scientific Paper Published

07.12.09

New paper from Sirius explains how our solubility measurements work, and introduces new methods for evaluating supersaturation.

Read more

New Scientific Paper Published

01.07.10

New paper - Study of pH-dependent solubility of organic bases. Revisit of Henderson-Hasselbalch relationship.

Read more

ACS Fall 2010 National Meeting, Boston

22.08.10

Sirius will exhibit at this meeting.

Read more

Physchem Forum 9, Barcelona

17.09.10

Sirius will exhibit at and sponsor the next Physchem Forum meeting in Barcelona

Read more

Main site navigation
HOME
PRODUCTS
INSTRUMENTATION
SiriusT3 - NEW
GLpKa
D-PAS
PCA200
Delta-8
Electrodes
GLpH
Vinotrate
SOFTWARE
RefinementPro 2
Fast D-PAS
Solubility
GI Dissolution - NEW
ANALYTICAL SERVICE
Medicinal Chemistry &    Hit to Lead
Preformulation
Formulation and Development
Consultancy
CUSTOMER SUPPORT
Maintenance
Service
Technical support
Material Safety Datasheets
Certificates of conformity
Electrode warranty forms
SCIENCE
PhysChem
pKa
logP
Solubility
Wine chemistry
TRAINING
Training sub menu
On-line training
In house training
Training courses in USA
Training courses in the UK
LITERATURE
Literature sub menu
Brochures
Bibliography
Posters
Slides
CONTACT
ABOUT
History
News archive
Events archive