Ag/AgCI, double junction reference
PCA200 - entry level pKa & logP titrator
Please note: We have discontinued production of new PCA200 systems due to the launch of its successor, the new SiriusT3.
Service and support for existing PCA200 customers will remain available until further notice.
Overview
Low cost auto titrator for entry level automation of pKa, logP/D, Solubility and Dissolution measurement
- pH-metric pKa, logP and logD
- pH range of 1.8 - 12.2 (for standard titrations)
- Fully automated probe movement, washing and calibration
- Built-in cosolvent methods for poorly soluble drugs
- Automatic results processing and QC checks
- Built-in traceability and maintenance reminders
- Temperature controlled sample position
PCA200 was a semi-automated instrument for high-quality measurement - Ideal for laboratories with a low sample throughput, or for academic research applications.
pKa is measured by automated potentiometric titration. LogP is also measured by a potentiometic method, based on a two-phase acid- base titration in a mixture of water and octanol.
specification
pH electrodes
Stirrer
Overhead, variable speed
Temperature probe
PT100, allows automatic temperature compensation
Precision dispensers
Acid and Base, minimum of 0.4µL with 5mL syringe
DualTip dispenser
Two quartz dispenser tubes
Probe movement
Fully automated X-Y axis
Washes
Two water washes and one special wash station provided
Electrode storage/calibration
Two pH7 buffer positions, one storage and one calibration
Single sample holder
Glass temperature control vessel (external circulating bath required)
Purge gas
Nitrogen or argon required
Partition solvents
Supports 7 including Octanol and a generic solvent
CoSolvents
Supports 10 including MeOH and DMSO
Keypad
Liquid-crystal 16-line display for text and graphics, 22-buttons for numeric data entry
System standardisation
Sirius Four-Plus(TM) procedure
Sample concentration
>0.5 mM (depending on the pH range)
pH-range
1.8 - 12.2
Assay volume
Minimum 5mL, maximum 20mL
Spectroscopy
Supports D-PAS
Services required
One mains power inlet (110 or 240 V)
Connection to the PC
Cable from PCA200 to PC serial comm port
Computer
Windows 2000 or XP
Software
PCA200 Firmware Version 2.107. RefinementPro Version 2.0.1.1
Reagent requirements
See 'pH-metric reagents' sheet
Dimension
600 x 440 x 520mm (WxDxH)
Weight of unit
25kg
Dimensions of packaging
900 x 800 x 750mm (WxDxH)
Weight of packed unit
Literature
Electronic copies of our PCA200 brochure and technical specifications are available for download:
> PCA200 Brochure> PCA200 Techinical Specifications
New Scientific Paper Published
07.12.09
New paper from Sirius explains how our solubility measurements work, and introduces new methods for evaluating supersaturation.
New Scientific Paper Published
01.07.10
New paper - Study of pH-dependent solubility of organic bases. Revisit of Henderson-Hasselbalch relationship.
Physchem Forum 9, Barcelona
17.09.10
Sirius will exhibit at and sponsor the next Physchem Forum meeting in Barcelona