Sirius SDI with ActipixTM Technology
Suface Dissoloution Imaging
The Sirius SDI (Surface Dissolution Imager) is a technological break-through in dissolution imaging. This instrument provides for the first time the ability to look directly at the solid-liquid interface as the dissolution process is happening. Real-time ultra-violet (UV) movies of the dissolution process can be gained microns from the drug surface using from as little as 2mg of sample and less than 20mL of dissolution medium within 30 minutes. The Sirius SDI includes award-winning ActiPix™ UV area imaging technology combined with a laminar flow-through sample holder, integrated syringe pump and software, enabling real-time recording and review of data. The flow cell provides a constant velocity of laminar flow, creating steady-state conditions to obtain reproducible values for each moment of flow. A 2 dimensional (2-D) array of pixels collects a series of images at pre-chosen wavelengths to provide absorbance data over a 2-D area. When combined with specialized software analysis tools, it provides a unique and time-saving insight into a compound’s performance. Physical changes and dissolution can be visualized simultaneously.
Used to accelerate pre-formulations development, the Sirius SDI enables intrinsic dissolution rates to be obtained in a fraction of time compared with conventional dissolution systems. From new drug discovery to compound formulation, the Sirius SDI will preserve precious test batches along with saving months in development time.
ActiPix™, the parallel array detector at the heart of SDI provides intensity measurements at every point inside the viewing area. Thousands of pixels detect photons over a large area. Individual pixels can be selected for measurement of absorbance values, and accurate measurement of location or distance relative to any origin from the dimensions of each pixel allows for dimensional analysis and distance profiling.
The absorbance values for each pixel in the selected viewing area create a 2-D image, and the images collected for the duration of the experiment are used to create a movie. High-resolution 2-D movies of UV absorbance can be captured, providing a detailed view of the dissolution process at the solid–liquid interface in real-time as it happens.