SiriusT3 - for pKa, logP/D & Solubility
Automated instrument for 'gold standard' measurement of ionization (pKa), lipophilicity (LogP/D), Solubility and Dissolution using sub milligram sample quantities.
The SiriusT3 allows physchem measurements to be performed on sub-milligram quantities of material. This revolution allows the best quality data to be obtained even on discovery compounds where sample quantity is a limiting factor. By obtaining high quality information at an earlier stage in the discovery and development process, decisions about chemistry changes and formulation routes can be made early, saving money, and potential problem areas in other assays can be identified and resolved with ease.
- Determine pKa values to the highest commercially available accuracy
- Generate distribution of species plots
- Determine buffer capacity
Understanding the ionisation state of a drug and how it varies with pH provides key information about the proportion of species available for absorption.
Running pKa determinations in different media reveals detailed information about how the pKa changes due to solvent interactions, partitioning, precipitation or binding.
- Determine logP
- Determine logD vs. pH
- Study octanol/water & many other mixtures
Understanding the logP and logD reveal how the ionisation state of the molecule influences its lipophilicity. This information can be used to improve ADME predictions as well as evaluating how changes to the molecule can increase/decrease the lipophilicity for a desired application.
- Determine intrinsic solubility
- Determine kinetic solubility
- Derive pH vs. solubility profile
- Determine supersaturation
Solubility is a complex and fundamental parameter affecting drug absorption. Understanding the full kinetics of supersaturation, precipitation, dissolution and the relationship between solubility and pH is crucial to understanding the ADME behaviour of a drug molecule.