Science

Solubility

Knowledge about the solubility of drugs is important  for several reasons. It helps resolve screening and bioavailability issues during  Discovery and Lead Optimization, and is valuable in planning chemistry changes and Biopharmaceutical evaluation.

In Development, it’s required for biopharmaceutical classification, biowaivers and bioequivalence. It’s also required for formulation optimization and salt selection. Solubility also affects the optimization of manufacturing processes.

Measurement of solubility is especially important during the enhancement of bioavailability and the development of formulations.