At Sirius Analytical we design and manufacture highly automated instruments to measure physicochemical parameters - pKa, logP & logD, solubility and dissolution. We also operate as a CRO providing a wide range of physical chemistry analytical services.
Acidity and Hydrophobicity of Several New Potential Antitubercular Drugs: Isoniazid and Benzimidazole Derivatives. Ràfols, C. Bosch, E. Ruiz R, Box, K. J, Reis, M. Ventura, C. Santos, S. Araújo,M.E. F, Martins. J. Chem. Eng. Data, 2011.
Abstract:
Hydrophobicity values (log Po/w) determined both by potentiometry and by the conventional shake-flask method and aqueous pKa values obtained by potentiometry for seven isoniazid and nine benzimidazole derivatives are presented. Several of these compounds have strong hydrophilic or hydrophobic character, and some of them show two or more ionizable sites, sometimes very acidic or very basic. These facts have compelled us to work near the limits of the potentiometric technique, and therefore, a critical evaluation of the results obtained in these extreme working conditions is presented. Particularly, details about the potentiometric determination of log Po/w values of the most hydrophilic and most hydrophobic compounds are clearly described.
For all those who were unable to attend the live webinar session or for those that would like to listen again click here to watch the full version.
Poor solubility can be critical for otherwise life-saving drugs, but new information could herald a welcome solution.
Our Chief Scientific Officer, John Comer and Dr Woei Ping Cheng of the University of Hertfordshire, recently spoke to Elly Earls about the latest developments in this fast-advancing field of solubility enhancement.
To read the full interview visit the Pharmaceutical Technology website.
Assay Expert combines the predictive power of ACD/Labs with the automation & experimental precision of the SiriusT3.
Sirius Analytical are pleased to announce the launch of Assay Expert a powerful new software tool developed in partnership with Advanced Chemistry Development, Inc., (ACD/Labs). With Assay Expert you can predict pKa, logP and solubility values prior to taking measurements on the SiriusT3 instrument - focusing experimental efforts.
Assay Expert creates a "Sample Model" with predicted values within the SiriusT3 software. The predictions are then used to optimize the experimental parameters and reduce the time it takes to measure accurate physchem results. In addition, the user will be able to examine the structure, identify ionic species and their distribution in aqueous solubility, and view a graphical output of the results.
Assay Expert dramatically decreases both the time and resource required to design and optimize a successful experiment, thus improving productivity.
For more information on how SiriusT3 and Assay expert can improve efficiencies within your lab, please contact us today.
The AAPS posters presented at the 2011 AAPS meeting are now available to download.
The webinar entitled 'Techniques for Investigating Supersaturation and the Enhancement of Solubility' was presented by John Comer, Sirius Technical Director, on October 19, 2011.
For all those who were unable to attend the live webinar session or for those that would like to listen again click here to watch the full version.
