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Training courses in the UK

The full training course takes place over five days. The first three days focus on GLpKa, and the second two on D-PAS. You may attend the whole course or either part depending on your training needs.

At all times, Sirius' expert applications chemists will be on-hand to answer your questions and provide you with the very latest assay design techniques and data processing methods.

You are welcome to bring along some of your own datasets for analysis during the course if you have problems with specific compounds that you would like to discuss. Training Room Places on the course are limited, and available on a first come/first served basis, so please register your interest as soon as possible to avoid disappointment.

For GLpKa, the 3 day course will cover:

Reagent preparation and standardization
pH electrode standardization and troubleshooting
pH-metric pKa and logP measurement theory
Optimizing assay design, with guided hands on examples in our laboratory
pKa of insoluble compounds using CoSolvents
Strategies for measuring very low or very high pKas
Measurement of extreme logP values
Dealing with protogenic counter-ions
Processing datasets in RefinementPro
Creating reports & exporting data
Instrument maintenance

For D-PAS, the 2 day course will cover:

Theory of spectroscopic determination of pKa
Instrument setup
Instrument control
Spectroscopic refinement
Assay design
Data refinement
CoSolvent assays
Single and multiset refinements
Hands-on assay setup and data processing of drug examples in our laboratory
Routine maintenance
Using D-PAS as a real-time turbidity probe

We have held over 40 GLpKa and PCA200 and D-PAS Courses.

Please let us know if you would like to attend a training course in the UK. We collect names of potential attendees until we have enough to fill a course (usually 4 to 6 delegates), and then fix the date of the course. This process happens by negotiation, so please don't be afraid to discuss your training needs with us.

Courses are held at Sirius headquarters in Forest Row, East Sussex, UK. Course fees cover tuition, lunch and materials including workbooks, slide copies and CDs of data. Fees do not include accommodation and transport. Reasonably-priced hotels and B & B accommodation are within walking distance of the course venue.